U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Oncolysis

MedGen UID:
90709
•Concept ID:
C0333516
•
Neoplastic Process
Synonyms: Neoplasm necrosis; Tumor necrosis
SNOMED CT: Tumor necrosis (34823008); Neoplasm necrosis (34823008); Oncolysis (34823008)

Definition

The destruction of tumor cells or a reduction in swelling. [from NCI]

Professional guidelines

PubMed

Remodeling the tumor microenvironment by oncolytic viruses: beyond oncolysis of tumor cells for cancer treatment.
Wang L, Chard Dunmall LS, Cheng Z, Wang Y
J Immunother Cancer 2022 May;10(5) doi: 10.1136/jitc-2021-004167. PMID: 35640930Free PMC Article
Molecular pathways: rodent parvoviruses--mechanisms of oncolysis and prospects for clinical cancer treatment.
Nüesch JP, Lacroix J, Marchini A, Rommelaere J
Clin Cancer Res 2012 Jul 1;18(13):3516-23. Epub 2012 May 7 doi: 10.1158/1078-0432.CCR-11-2325. PMID: 22566376
Adenoviruses for treatment of cancer.
Kanerva A, Hemminki A
Ann Med 2005;37(1):33-43. doi: 10.1080/07853890410018934. PMID: 15902845

Recent clinical studies

Etiology

Targeting NKG2D ligands in glioblastoma with a bispecific T-cell engager is augmented with conventional therapy and enhances oncolytic virotherapy of glioma stem-like cells.
Baugh R, Khalique H, Page E, Lei-Rossmann J, Wan PK, Johanssen T, Ebner D, Ansorge O, Seymour LW
J Immunother Cancer 2024 May 9;12(5) doi: 10.1136/jitc-2023-008460. PMID: 38724464Free PMC Article
Oncolytic adenovirus in treating malignant ascites: A phase II trial and longitudinal single-cell study.
Zhang Y, Qian L, Chen K, Gu S, Meng Z, Wang J, Li Y, Wang P
Mol Ther 2024 Jun 5;32(6):2000-2020. Epub 2024 Apr 24 doi: 10.1016/j.ymthe.2024.04.029. PMID: 38659226Free PMC Article
Unlocking the potential of dimethyl fumarate: enhancing oncolytic HSV-1 efficacy for wider cancer applications.
Alwithenani A, Taha Z, Thomson M, Chen A, Wong B, Arulanandam R, Diallo JS
Front Immunol 2023;14:1332929. Epub 2023 Dec 19 doi: 10.3389/fimmu.2023.1332929. PMID: 38169670Free PMC Article
Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.
Lang FF, Conrad C, Gomez-Manzano C, Yung WKA, Sawaya R, Weinberg JS, Prabhu SS, Rao G, Fuller GN, Aldape KD, Gumin J, Vence LM, Wistuba I, Rodriguez-Canales J, Villalobos PA, Dirven CMF, Tejada S, Valle RD, Alonso MM, Ewald B, Peterkin JJ, Tufaro F, Fueyo J
J Clin Oncol 2018 May 10;36(14):1419-1427. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.8219. PMID: 29432077Free PMC Article
Gene therapy for cancer and metastatic disease.
Kesmodel SB, Spitz FR
Expert Rev Mol Med 2003 Jun 3;5(17):1-18. doi: 10.1017/S1462399403006380. PMID: 14585164

Diagnosis

Targeting NKG2D ligands in glioblastoma with a bispecific T-cell engager is augmented with conventional therapy and enhances oncolytic virotherapy of glioma stem-like cells.
Baugh R, Khalique H, Page E, Lei-Rossmann J, Wan PK, Johanssen T, Ebner D, Ansorge O, Seymour LW
J Immunother Cancer 2024 May 9;12(5) doi: 10.1136/jitc-2023-008460. PMID: 38724464Free PMC Article
SOCS3 inhibiting JAK-STAT pathway enhances oncolytic adenovirus efficacy by potentiating viral replication and T-cell activation.
Yan D, Li G, Yuan Y, Li H, Cao H, Dai Y, Li Y, Zhang Z, Li F, Fang Y, Gao Q
Cancer Gene Ther 2024 Mar;31(3):397-409. Epub 2023 Dec 15 doi: 10.1038/s41417-023-00710-2. PMID: 38102464
Oxidative stress enhances rotavirus oncolysis in breast cancer and leukemia, except in melanoma with abundant matrix.
Guerrero M, Hernández J, Gomez L, Guerrero C
Virus Res 2024 Jan 2;339:199285. Epub 2023 Nov 27 doi: 10.1016/j.virusres.2023.199285. PMID: 38013142Free PMC Article
Unlocking the potential of dimethyl fumarate: enhancing oncolytic HSV-1 efficacy for wider cancer applications.
Alwithenani A, Taha Z, Thomson M, Chen A, Wong B, Arulanandam R, Diallo JS
Front Immunol 2023;14:1332929. Epub 2023 Dec 19 doi: 10.3389/fimmu.2023.1332929. PMID: 38169670Free PMC Article
Viral oncolysis.
Mullen JT, Tanabe KK
Oncologist 2002;7(2):106-19. doi: 10.1634/theoncologist.7-2-106. PMID: 11961194

Therapy

Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis.
Tan IL, Perez AR, Lew RJ, Sun X, Baldwin A, Zhu YK, Shah MM, Berger MS, Doudna JA, Fellmann C
Cell Rep 2023 Nov 28;42(11):113339. Epub 2023 Nov 2 doi: 10.1016/j.celrep.2023.113339. PMID: 37917583Free PMC Article
Poxvirus oncolytic virotherapy.
Torres-Domínguez LE, McFadden G
Expert Opin Biol Ther 2019 Jun;19(6):561-573. Epub 2019 Apr 4 doi: 10.1080/14712598.2019.1600669. PMID: 30919708
Oncolytic viruses and immunity.
Chaurasiya S, Chen NG, Fong Y
Curr Opin Immunol 2018 Apr;51:83-90. Epub 2018 Mar 16 doi: 10.1016/j.coi.2018.03.008. PMID: 29550660Free PMC Article
Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.
Lang FF, Conrad C, Gomez-Manzano C, Yung WKA, Sawaya R, Weinberg JS, Prabhu SS, Rao G, Fuller GN, Aldape KD, Gumin J, Vence LM, Wistuba I, Rodriguez-Canales J, Villalobos PA, Dirven CMF, Tejada S, Valle RD, Alonso MM, Ewald B, Peterkin JJ, Tufaro F, Fueyo J
J Clin Oncol 2018 May 10;36(14):1419-1427. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.8219. PMID: 29432077Free PMC Article
Viral oncolysis.
Mullen JT, Tanabe KK
Oncologist 2002;7(2):106-19. doi: 10.1634/theoncologist.7-2-106. PMID: 11961194

Prognosis

Patient-derived tumoroids and proteomic signatures: tools for early drug discovery.
Lê H, Deforges J, Cutolo P, Lamarque A, Hua G, Lindner V, Jain S, Balloul JM, Benkirane-Jessel N, Quéméneur E
Front Immunol 2024;15:1379613. Epub 2024 Apr 18 doi: 10.3389/fimmu.2024.1379613. PMID: 38698850Free PMC Article
STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1.
Song D, Jia X, Gao Y, Xiao T, Dan J, Shen R, Cai J, Liang J, Zhu W, Hu J, Yan G, Zhang Q, Lin Y
Oncogene 2023 Nov;42(48):3575-3588. Epub 2023 Oct 20 doi: 10.1038/s41388-023-02872-7. PMID: 37864032
Determinants of the efficacy of viro-immunotherapy: A review.
de Graaf JF, Huberts M, Fouchier RAM, van den Hoogen BG
Cytokine Growth Factor Rev 2020 Dec;56:124-132. Epub 2020 Sep 6 doi: 10.1016/j.cytogfr.2020.07.001. PMID: 32919831
Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.
Lang FF, Conrad C, Gomez-Manzano C, Yung WKA, Sawaya R, Weinberg JS, Prabhu SS, Rao G, Fuller GN, Aldape KD, Gumin J, Vence LM, Wistuba I, Rodriguez-Canales J, Villalobos PA, Dirven CMF, Tejada S, Valle RD, Alonso MM, Ewald B, Peterkin JJ, Tufaro F, Fueyo J
J Clin Oncol 2018 May 10;36(14):1419-1427. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.8219. PMID: 29432077Free PMC Article
Oncolytic virotherapy as an immunotherapeutic strategy for multiple myeloma.
Meyers DE, Thakur S, Thirukkumaran CM, Morris DG
Blood Cancer J 2017 Dec 5;7(12):640. doi: 10.1038/s41408-017-0020-0. PMID: 29208938Free PMC Article

Clinical prediction guides

Patient-derived tumoroids and proteomic signatures: tools for early drug discovery.
Lê H, Deforges J, Cutolo P, Lamarque A, Hua G, Lindner V, Jain S, Balloul JM, Benkirane-Jessel N, Quéméneur E
Front Immunol 2024;15:1379613. Epub 2024 Apr 18 doi: 10.3389/fimmu.2024.1379613. PMID: 38698850Free PMC Article
STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1.
Song D, Jia X, Gao Y, Xiao T, Dan J, Shen R, Cai J, Liang J, Zhu W, Hu J, Yan G, Zhang Q, Lin Y
Oncogene 2023 Nov;42(48):3575-3588. Epub 2023 Oct 20 doi: 10.1038/s41388-023-02872-7. PMID: 37864032
Determinants of the efficacy of viro-immunotherapy: A review.
de Graaf JF, Huberts M, Fouchier RAM, van den Hoogen BG
Cytokine Growth Factor Rev 2020 Dec;56:124-132. Epub 2020 Sep 6 doi: 10.1016/j.cytogfr.2020.07.001. PMID: 32919831
Mechanisms of measles virus oncolytic immunotherapy.
Pidelaserra-Martí G, Engeland CE
Cytokine Growth Factor Rev 2020 Dec;56:28-38. Epub 2020 Jul 3 doi: 10.1016/j.cytogfr.2020.07.009. PMID: 32660751
Reovirus and tumor oncolysis.
Kim M, Chung YH, Johnston RN
J Microbiol 2007 Jun;45(3):187-92. PMID: 17618222

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...